⚠️ Important warning – Specific reconstitution of HGH Fragment 176–191

Each peptide is normally supplied with 1 ml of water for injections.
For this batch of HGH Fragment 176–191, however, 3 ml of water is required, not 1 ml.

Using a smaller volume may cause crystallization or solidification of the peptide after refrigeration.

👉 We therefore recommend purchasing an additional 10 ml vial of water for injections.

We apologize for the inconvenience and thank you for your understanding.

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💡 Recommended storage conditions – HGH Fragment 176–191

To ensure the stability of the solution and prevent the formation of sediment or gel, follow these instructions:

After reconstitution

• Let the solution rest for 5–10 minutes at room temperature.

• Do not immediately place the vial in the refrigerator.

During storage

• Store the vial in the refrigerator door (ideal temperature 4–6 °C).

• Evitare zone troppo fredde (<2 °C) e il congelamento

• Avoid frequent or sudden temperature changes

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Description

Active ingredient: HGH Fragment 176–191
Type: peptide hormone
Form: injectable

This peptide, also known as AOD9604, represents the fragment of the growth hormone composed of amino acids 176–191, which are specifically responsible for fat burning.

Preclinical studies on animals and in vitro tests on human adipose tissue have confirmed its effectiveness in reducing fat mass, making it the subject of great scientific interest, especially in the treatment of obesity.

Obesity is a widespread global condition and is associated with numerous diseases, including diabetes, cardiovascular disease, and cancer. Recombinant growth hormone was initially considered a possible solution, but its clinical use has proved limited due to insulin resistance, edema, hypertension, and poor long-term tolerability.

For this reason, HGH Fragment 176–191 was developed as a safer and more targeted alternative.

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Mechanism of action

HGH Fragment directly stimulates lipid metabolism, acting selectively on adipose tissue.
It is capable of:

• increasefat oxidation

• stimulate lipolysis

• reduce lipogenesis

These effects have been observed in vivo, ex vivo, and in vitro.

The peptide increases the expression of the β3-adrenergic receptor, a key element of the sympathetic nervous system involved in adipocyte destruction and thermoregulation. However, this is not the only mechanism of action.

Analyses on human adipose tissue have shown:

• significant reduction in lipogenic activity

• marked increase in lipolytic activity

• increase in energy expenditure and oxidation of carbohydrates and lipids

Overall, HGH Fragment modifies fat metabolism, leading to reduced weight gain in obese animals, with promising results for humans as well.

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Key benefits

• Powerful lipolytic effect

• Absence of the typical side effects of GH

• Does not bind to growth hormone receptors

• Does not increase serum IGF-1

• No negative impact on carbohydrate metabolism

• Does not induce antibody formation

• Safety profile comparable to placebo

Unlike GH, HGH Fragment does not cause edema, insulin resistance, or hypertension.

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Effects

• Reduction of subcutaneous fat

• Possible positive effect on cartilage (observed in intra-articular studies, to be clinically confirmed)

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Side effects

Studies indicate very high tolerability.
In rare cases, the following may occur:

• mild burning sensation

• itching at the injection site

These symptoms usually disappear within a few minutes.

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Dosage and use

• Recommended daily dose: 250–1000 mcg

• Most common dose: 500 mcg

The duration of the cycle is not standardized. In sports practice, it varies from a few months to:

• personal goals

• diet

• other drugs used at the same time

⚠️ The peptide is more effective when combined with a low-fat diet.

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Combinations

HGH Fragment can be used in combination with:

• growth hormone

• GHRP

• IGF-1

These combinations can generate a synergistic effect in reducing body fat.

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Preparation of the solution

1. Draw up the thinner with a syringe.

2. Inject slowly along the wall of the vial containing the lyophilized powder.

3. Do not inject directly onto the powder

4. Gently stir (do not shake) until the solution is clear.

⚠️ Never mix different peptides in the same syringe.

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Method of administration

• Subcutaneous or intramuscular injection, as preferred

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Storage

• Store the reconstituted solution in a refrigerator at 2–8°C.

• Average duration: approximately 21 days

• Stability increases if bacteriostatic water is used.