What is Sildenafil – Viagra?

Sildenafil – Viagra is one of the best-known and most effective drugs for treating male erectile dysfunction. The active ingredient, sildenafil citrate, is clinically approved to improve the ability to achieve and maintain an erection in the presence of sexual stimulation.

Originally developed as a treatment for angina pectoris, sildenafil demonstrated a marked positive effect on erectile function during clinical trials. This discovery led to its approval as a standard treatment for erectile dysfunction, making it known worldwide under the trade name Viagra.

In addition to its use in treating erectile dysfunction, Sildenafil – Viagra is also approved for the treatmentof pulmonary arterial hypertension, thanks to its ability to reduce vascular resistance and improve exercise tolerance.

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Main benefits of Sildenafil – Viagra

Treatment of erectile dysfunction

Sildenafil – Viagra promotes a natural erection by increasing blood flow to the penis during sexual arousal. It improves sexual performance, personal confidence, and quality of life, helping millions of men worldwide overcome erection problems.

Support for pulmonary arterial hypertension

Sildenafil works by relaxing the blood vessels in the lungs, reducing pressure in the pulmonary arteries. This helps slow the progression of the disease and improve exercise capacity.

Cardiovascular benefits

Scientific studies indicate that Sildenafil – Viagra can improve endothelial function, optimize blood flow regulation, and reduce oxidative stress, with positive effects on the cardiovascular system.

Improvement in physical capacity

Thanks to vasodilation and improved oxygen transport to tissues, sildenafil can contribute to greater physical endurance, reducing fatigue during sports activities.

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Mechanism of action of Sildenafil – Viagra

Sildenafil – Viagra belongs to the class of selective phosphodiesterase type 5 (PDE5) inhibitors.

During sexual stimulation:

• nitric oxide (NO) is released,

• increases cGMP production,

• the smooth muscles of the penis relax,

• blood vessels dilate,

• Blood flow increases, promoting erection.

PDE5 normally breaks down cGMP. Sildenafil blocks this enzyme, prolonging the vasodilator effect and allowing for a more stable and longer-lasting erection, exclusively in the presence of sexual stimulation.

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Pharmacokinetics

• Absorption: rapid, with effect generally within 30–60 minutes

• Influence of food: meals high in fat can slow down absorption

• Half-life: approximately 4 hours

• Metabolism: hepatic (CYP3A4 and CYP2C9)

• Elimination: mainly in the feces, partly in the urine

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Main uses

• Improvement of erectile function

• Increased peripheral blood flow

• Support for vascular health

• Improvement in physical performance and endurance

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Dosage and method of administration

• Recommended starting dose: 50 mg

• Maximum dose: 100 mg

• Directions for use: take approximately 30–60 minutes before sexual activity.

• Frequency: no more than once a day

For pulmonary hypertension, the dosage is different and must be determined by your doctor.

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Possible side effects

The most common side effects include:

• headache

• blushing

• nasal congestion

• digestive disorders

• minor visual disturbances

Rare but serious side effects include priapism, sudden hearing loss, or cardiovascular events, especially in predisposed individuals.

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Precautions and contraindications

• Do not take with nitrates or nitric oxide donors.

• Use caution in cases of cardiovascular disease.

• Avoid excessive alcohol consumption

• Consult your doctor if you have liver or kidney disease.

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Storage

• Store at room temperature

• Keep away from light, moisture, and heat.

• Keep out of reach of children

• Do not use after the expiration date

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