HCG – Human Chorionic Gonadotropin

Composition: human chorionic gonadotropin (HCG) 5000 IU.
Category: peptide, hormonal support during and after the cycle.
Purpose: stimulation of gonadal activity, maintenance of endogenous testosterone production, and support for reproductive function recovery.
Form: vial containing lyophilized powder + 1 ml ampoule of water for injections for reconstitution.
Administration: subcutaneous injection.

Shipping (if the product is in stock): 3 business days for processing and 5 to 20 business days for shipping
Processing and shipping costs: €27 throughout Italy

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What is hCG (Gonase)?

Human chorionic gonadotropin, commonly referred to as hCG and also marketed as Gonase, is a peptide hormone produced naturally during pregnancy. In sports and clinical settings, it is used to maintain and restore endogenous testosterone production when the hormonal axis is suppressed, for example during cycles of anabolic steroids (AAS).

hCG/Gonase mimics luteinizing hormone (LH) by binding to its receptors in Leydig cells and stimulating testosterone synthesis. In medicine, it was initially used to induce ovulation in women and support spermatogenesis and fertility in men; it later became a mainstay of hormonal support in athletes.

Main effects of hCG (Gonase)

📈 Maintains and increases endogenous testosterone during AAS suppression
🧬 Supports fertility and libido
⚙️ Preserves testicular volume and function, preventing atrophy
🔁 Helps hormonal balance during prolonged cycles

How to take hCG (Gonase)

Before use, learn about reconstitution and injection technique. hCG is particularly indicated for cycles longer than 6 weeks.

Typical diagram

Purpose	Dosage	Frequency	Duration
During AAS cycle (from week 4)	~1000 IU/week (750–1250 IU)	2 injections of 500 IU	Until the end of the cycle
Libido/energy support	500 IU	1–2 times per week	2–4 weeks

📌 Monitor: total/free testosterone, LH, FSH, estradiol, prolactin; in long cycles also β-hCG.

Precautions

Do not combine SERMs (clomiphene, tamoxifen) with hCG; reserve them for PCT.
Avoid combining with other gonadotropins or LH mimetics.
Watch out for signs of excess estrogen (edema, nipple sensitivity).
Use moderate doses to avoid desensitization of LH receptors.

Possible side effects

Increased estrogen (with overdose)
Testicular tenderness or swelling
Mood swings, fatigue

Storage

Refrigerator 2–8 °C, protected from light and heat
After reconstitution: 1–2 months if stored correctly

How hCG (Gonase) works

hCG is a "functional duplicate of LH": it maintains intratesticular testosterone (ITT) and gonadal function even when the HPG axis is suppressed by AAS. This makes it ideal during the cycle, while in PCT it is preferable to reactivate the upper branch (hypothalamus/pituitary gland) with SERMs.

Clinical studies (Coviello 2005; Roth 2010–2011) show that low–moderate doses of hCG maintain ITT at near-physiological levels with a dose-dependent response up to the threshold, confirming the importance of avoiding excesses.

Quick FAQs

When to start? Around week 4 of the AAS cycle.
In PCT? No, stop first and switch to SERMs.
Fat loss? Indirectly, yes, by supporting testosterone, energy, and lean mass.